Lots of references:
First A-Bomb Test--Gigabyte says "I am become Gigabyte, the Destroyer of Mainframe." This is reference to the line from the Bhagvad Gita, which Robert Openhiemer reportedly remembered after seeing the blast ("I am become Death, the destroyer of worlds").
Nightmare on Elm Street--Gigabyte scrapes his claws on the wall, just as Freddy did in this film.
Raiders of the Lost Ark--Gig drains a sprite that is dressed just like Indy Jones.
This episode serves mainly to reintroduce Mouse and Ship to Mainfraime. She stays for the duration of the series.
It's interesting how this episode figures in season 4, bringing back Gigabyte and Glitch's splitter function.